Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00179)
MIC Name Bacteroides thetaiotaomicron (CFB bacteria)
MIC Synonyms Bacillus thetaiotaomicron
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides thetaiotaomicron
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 6487685
No. of Coding Genes 5071
No. of Non-Coding Genes 88
No. of Small Non-Coding Genes 88
No. of Gene Transcripts 5159
No. of Base Pairs 6487685
Description Bacteroides thetaiotaomicron, a Gram-negative anaerobic microbe, resides in and dominates the human intestinal tract which was nitially isolated from fecal matter. However, it is also a key anaerobic, Gram-negative bacterial pathogen with extreme disease causing potential as well as antibiotic resistance, which is of clinical interest. It was found associated with Colitis.
External Links Taxonomy ID
818
Genome Assembly ID
ASM131497v1
GOLD Organism ID
Go0519815
Disease Relevance
          Coeliac disease  [ICD-11: DA95]
             Description Bacteroides thetaiotaomicron Bacteroides uniformis was more abundant in controls than in patients with coeliac disease. [1]
          Infectious endocarditis  [ICD-11: BB40]
             Description Bacteroides thetaiotaomicron 7332 was associated with endocarditis. [2]
          Obesity  [ICD-11: 5B81]
             Description A lower abundance of the glutamate metabolic bacteria Bacteroides thetaiotaomicron was associated with obesity. [3]
          Peritonitis  [ICD-11: DC50]
             Description Bacteroides thetaiotaomicron 7333 was associated with peritonitis. [4]
          Sepsis  [ICD-11: 1G41]
             Description Bacteroides thetaiotaomicron 7330 was associated with intra-abdominal sepsis. [5]
          Vibrio mimicus gastroenteritis  [ICD-11: 1A40]
             Description Bacteroides thetaiotaomicron 7331 was associated with colitis. [6]
Host Immune Factors (HIFs)
          Angiogenin-4
             HIF ID HIFM0005 HIF Info       Class Antimicrobial peptide (AMP)
             Description The intestinal commensal Bacteroides thetaiotaomicron was less sensitive: the number of viable organisms was reduced only 30% with 1 M of Ang4. [7]
          Bradykinin
             HIF ID HIFM0160 HIF Info       Class Antimicrobial peptide (AMP)
             Description Bacteroides thetaiotaomicron induced release of bradykinin through regulatory affinity to from high-molecular-mass kininogen in human plasma. [8]
          Regenerating islet-derived protein 3-gamma
             HIF ID HIFM0198 HIF Info       Class Antimicrobial peptide (AMP)
             Description Monocolonization of germ-free mice with Gram-negative Bacteroides thetaiotaomicron resulted in a modest upregulation of RegIII gamma(2.5-fold). [9]
          Human resistin
             HIF ID HIFM0199 HIF Info       Class Antimicrobial peptide (AMP)
             Description Bacteroides thetaiotaomicron was resistant to hRETN. [10]
          Perforin
             HIF ID HIFM0320 HIF Info       Class Antimicrobial peptide (AMP)
             Description Membrane-attack complex/perforin (MACPF) family protein is from the human gut symbiont Bacteroides thetaiotaomicron. [11]
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description Oral feeding with Bacteroides thetaiotaomicron recovered anti-CTLA-4 response. [12]
          Programmed Cell Death 1 Protein
             HIF ID HIFM0191 HIF Info       Class Checkpoint molecule (CM)
             Description Bacteroides thetaiotaomicron have been negatively associated with response to anti-PD-1 therapy. [12]
          Tumor necrosis factor ligand superfamily member 15
             HIF ID HIFM0224 HIF Info       Class Checkpoint molecule (CM)
             Description The Bacteroides thetaiotaomicron could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [13]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Bacteroides thetaiotaomicron at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease. [14]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description IgG could response to Bacteroides thetaiotaomicron. [15]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description IgA could interact with Bacteroides thetaiotaomicron. [16]
          FOXP3+ regulatory T cells
             HIF ID HIFC0033 HIF Info       Class T cells (TCs)
             Description Bacteroides thetaiotaomicron has been shown to induce the accumulation of FOXP3+ pTreg cells. [17]
          CD103+NRP1 Helios RORt+FOXP3+CD4+ regulatory T cells
             HIF ID HIFC0188 HIF Info       Class T cells (TCs)
             Description Bacteroides thetaiotaomicron is related to the increase of CD103+NRP1HeliosRORt+FOXP3+CD4+ Treg cells in the colon. [17]
          NRP1 RORt+ regulatory T cells
             HIF ID HIFC0224 HIF Info       Class T cells (TCs)
             Description Bacteroides thetaiotaomicron has been shown to induce the accumulation number of NRP1RORt+ pTreg cells. [17]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description Bacteroides thetaiotaomicron LPS can stimulate cells via TLR4. [18]
Environmental Factor(s)
             Disbiome ID
      163
             gutMDisorder ID
      gm0087
References
1 Intestinal Bacteroides species associated with coeliac disease. J Clin Pathol. 2010 Dec;63(12):1105-11. doi: 10.1136/jcp.2010.076950. Epub 2010 Oct 23.
2 Trends and emerging directions in HIV risk and prevention research in the Philippines: A systematic review of the literature. PLoS One. 2018 Dec 5;13(12):e0207663. doi: 10.1371/journal.pone.0207663. eCollection 2018.
3 Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder. mSystems. 2019 Jan 29;4(1):e00321-18. doi: 10.1128/mSystems.00321-18. eCollection 2019 Jan-Feb.
4 Belowground fungal community diversity and composition associated with Norway spruce along an altitudinal gradient. PLoS One. 2018 Dec 5;13(12):e0208493. doi: 10.1371/journal.pone.0208493. eCollection 2018.
5 Cervical dysplasia in elderly women performing repeated self-sampling for HPV testing. PLoS One. 2018 Dec 5;13(12):e0207714. doi: 10.1371/journal.pone.0207714. eCollection 2018.
6 Herbivory of oil-exposed submerged aquatic vegetation Ruppia maritima. PLoS One. 2018 Dec 5;13(12):e0208463. doi: 10.1371/journal.pone.0208463. eCollection 2018.
7 Angiogenins: a new class of microbicidal proteins involved in innate immunity.Nat Immunol. 2003 Mar;4(3):269-73. doi: 10.1038/ni888. Epub 2003 Jan 27.
8 Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system.Microbiology. 2011 Jul;157(Pt 7):2094-2105. doi: 10.1099/mic.0.046862-0. Epub 2011 Apr 28.
9 The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria.Front Immunol. 2020 May 20;11:965. doi: 10.3389/fimmu.2020.00965. eCollection 2020.
10 Resistin-like molecule is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11027-11033. doi: 10.1073/pnas.1711395114. Epub 2017 Sep 25.
11 Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1297-305. doi: 10.1107/S1744309110023055. Epub 2010 Jul 31.
12 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
13 Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.Eur J Immunol. 2009 Nov;39(11):3239-50. doi: 10.1002/eji.200839087.
14 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
15 Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota.Cell. 2018 Jun 14;173(7):1742-1754.e17. doi: 10.1016/j.cell.2018.05.008.
16 The antibody/microbiota interface in health and disease.Mucosal Immunol. 2020 Jan;13(1):3-11. doi: 10.1038/s41385-019-0192-y. Epub 2019 Aug 14.
17 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.
18 The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses. Microb Pathog. 2009 Aug;47(2):68-77. doi: 10.1016/j.micpath.2009.04.015. Epub 2009 May 19.

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