General Information of MIC (ID: MIC00949)
MIC Name Parabacteroides distasonis (CFB bacteria)
MIC Synonyms Ristella distasonis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides distasonis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 4811379
Description Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. It may be useful in the development of new therapeutic strategies for chronic inflammatory disorders such as inflammatory bowel disease. But it cause splenic abscess in sickle cell patients.
External Links Taxonomy ID
823
Genome Assembly ID
ASM1284v1
GOLD Organism ID
Go0000125
Disease Relevance
          Amyotrophic lateral sclerosis  [ICD-11: 8B60]
             Description Parabacteroides distasonis exacerbated the symptoms of amyotrophic lateral sclerosis. [1]
          Autism spectrum disorder  [ICD-11: 6A02]
             Description A decrease in the abundance of Parabacteroides in the Autism Spectrum Disorder cohort. [2]
          Coeliac disease  [ICD-11: DA95]
             Description Bacteroides distasonis Bacteroides uniformis was more abundant in controls than in patients with coeliac disease. [3]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Parabacteroides distasonis was associated with inflammatory bowel disease. [4]
          Splenic abscess  [ICD-11: 3B81]
             Description Parabacteroides distasonis was associated with splenic abscess. [5]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Parabacteroides was associated with genetic variants in Type 2 diabetes. [6]
Host Genetic Factors (HGFs)
          VDR
             HGF ID HGF2353 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of VDR has been associated with the decreased amount of Parabacteroides distasonis. [7]
          KLB
             HGF ID HGF2334 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of KLB increased the proportion of Parabacteroides. [8]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Parabacteroides distasonis [9]
          rs9376837
             HGF ID HGF1243 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9376837 SNP is significantly associated with the abundance of Parabacteroides (p-value=4.31294E-07). [10]
          rs10493180
             HGF ID HGF1513 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10493180 SNP was significantly associated with the abundance of Parabacteroides (p-value=2.92E-07). [11]
          rs10486483
             HGF ID HGF2543 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10486483 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs2188962
             HGF ID HGF2640 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2188962 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs3197999
             HGF ID HGF2627 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs3197999 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs17391694
             HGF ID HGF2641 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17391694 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs5763767
             HGF ID HGF2642 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5763767 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs12942547
             HGF ID HGF2643 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12942547 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs11230563
             HGF ID HGF2644 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs11230563 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs1569328
             HGF ID HGF2571 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1569328 SNP is associated with the abundance of Parabacteroides distasonis. [12]
          rs6667605
             HGF ID HGF2621 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6667605 SNP is associated with the abundance of Parabacteroides distasonis. [12]
Host Immune Factors (HIFs)
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in B cells.. [13]
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description The abundance of Parabacteroides distasonis(of the Bacteroidales order) have been associated with response to CTLA-4 blockade in humans. [14]
          Granulocyte colony-stimulating factor
             HIF ID HIFM0067 HIF Info       Class Cytokine (Cyt)
             Description Parabacteroides distasonis is associated with the expression of G-CSF. [15]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The increase production in IL-10 in the Parabacteroides distasonis colon from PBS-treated healthy mice. [15]
          Interleukin-12 subunit beta
             HIF ID HIFM0131 HIF Info       Class Cytokine (Cyt)
             Description Parabacteroides distasonis is associated with interleukin (IL)-l12p40p70. [15]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Parabacteroides distasonis is associated with IL-6 expression. [15]
          Transforming growth factor beta-2 proprotein
             HIF ID HIFM0213 HIF Info       Class Cytokine (Cyt)
             Description Parabacteroides distasonis is associated with TGF- concentrations. [15]
          M1 macrophages
             HIF ID HIFC0019 HIF Info       Class Macrophages (Mac)
             Description Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in M1 macrophages.. [13]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in CD4+ T cells. [13]
          CD4+CD25+FOXP3+ regulatory T cells
             HIF ID HIFC0036 HIF Info       Class T cells (TCs)
             Description Parabacteroides distasonis induced an increase in CD4+CD25+FoxP3+Treg cells. [15]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in CD8+ T cells. [13]
          Splenocytes
             HIF ID HIFC0091 HIF Info       Class T cells (TCs)
             Description Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in splenocytes. [13]
          CD103+Helios CD4+CD25+FOXP3+ regulatory T cells
             HIF ID HIFC0186 HIF Info       Class T cells (TCs)
             Description Bacteroides distasonis is related to the expansion of colonic CD103+HeliosCD4+CD25+FOXP3+ Treg cell population. [16]
Environmental Factor(s)
             Disbiome ID
      183
             gutMDisorder ID
      gm0496
References
1 Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature. 2019 Aug;572(7770):474-480. doi: 10.1038/s41586-019-1443-5. Epub 2019 Jul 22.
2 New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome. 2017 Feb 22;5(1):24. doi: 10.1186/s40168-017-0242-1.
3 Intestinal Bacteroides species associated with coeliac disease. J Clin Pathol. 2010 Dec;63(12):1105-11. doi: 10.1136/jcp.2010.076950. Epub 2010 Oct 23.
4 Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice. PLoS One. 2016 Jan 4;11(1):e0146162. doi: 10.1371/journal.pone.0146162. eCollection 2016.
5 Cloxacillin control of experimental arthritis induced by SEC(+) Staphylococcus aureus is associated with downmodulation of local and systemic cytokines. Cell Microbiol. 2016 Jul;18(7):998-1008. doi: 10.1111/cmi.12563. Epub 2016 Feb 1.
6 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
7 Vitamin D receptor promotes healthy microbial metabolites and microbiome.Sci Rep. 2020 Apr 30;10(1):7340. doi: 10.1038/s41598-020-64226-7.
8 -Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.JCI Insight. 2017 Apr 20;2(8):e91809. doi: 10.1172/jci.insight.91809. eCollection 2017 Apr 20.
9 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
10 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
11 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
12 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
13 Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses. Food Funct. 2020 Jan 29;11(1):153-162. doi: 10.1039/c9fo01740b.
14 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
15 Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol. 2011 Feb;163(2):250-9. doi: 10.1111/j.1365-2249.2010.04286.x. Epub 2010 Nov 19.
16 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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