Details of Microbe Species (MIC)
General Information of MIC (ID: MIC00949) | |||||
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MIC Name | Parabacteroides distasonis (CFB bacteria) | ||||
MIC Synonyms | Ristella distasonis | ||||
Body Site | Gut | ||||
Lineage | Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Tannerellaceae Genus: Parabacteroides Species: Parabacteroides distasonis | ||||
Oxygen Sensitivity | Obligate anaerobe | ||||
Microbial Metabolism | Saccharolytic; Fermentative | ||||
Gram | Negative | ||||
Host Relationship | Commensal | ||||
Genome Size (bp) | 4811379 | ||||
Description | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. It may be useful in the development of new therapeutic strategies for chronic inflammatory disorders such as inflammatory bowel disease. But it cause splenic abscess in sickle cell patients. | ||||
External Links | Taxonomy ID | ||||
Genome Assembly ID | |||||
GOLD Organism ID | |||||
Disease Relevance | |||||
Amyotrophic lateral sclerosis [ICD-11: 8B60] | |||||
Description | Parabacteroides distasonis exacerbated the symptoms of amyotrophic lateral sclerosis. | [1] | |||
Autism spectrum disorder [ICD-11: 6A02] | |||||
Description | A decrease in the abundance of Parabacteroides in the Autism Spectrum Disorder cohort. | [2] | |||
Coeliac disease [ICD-11: DA95] | |||||
Description | Bacteroides distasonis Bacteroides uniformis was more abundant in controls than in patients with coeliac disease. | [3] | |||
Inflammatory bowel disease [ICD-11: DD72] | |||||
Description | Parabacteroides distasonis was associated with inflammatory bowel disease. | [4] | |||
Splenic abscess [ICD-11: 3B81] | |||||
Description | Parabacteroides distasonis was associated with splenic abscess. | [5] | |||
Type 2 diabetes mellitus [ICD-11: 5A11] | |||||
Description | Parabacteroides was associated with genetic variants in Type 2 diabetes. | [6] | |||
Host Genetic Factors (HGFs) | |||||
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VDR | |||||
HGF ID | HGF2353 | HGF Info | Class | Copy Number Variation: Gene Deletion (CNV-GDe) | |
Description | The deletion of VDR has been associated with the decreased amount of Parabacteroides distasonis. | [7] | |||
KLB | |||||
HGF ID | HGF2334 | HGF Info | Class | Copy Number Variation: Gene Deletion (CNV-GDe) | |
Description | The deletion of KLB increased the proportion of Parabacteroides. | [8] | |||
SLC15A1 | |||||
HGF ID | HGF2354 | HGF Info | Class | Copy Number Variation: Gene Deletion (CNV-GDe) | |
Description | The deletion of PepT1 could decrease the abundance of Parabacteroides distasonis | [9] | |||
rs9376837 | |||||
HGF ID | HGF1243 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs9376837 SNP is significantly associated with the abundance of Parabacteroides (p-value=4.31294E-07). | [10] | |||
rs10493180 | |||||
HGF ID | HGF1513 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs10493180 SNP was significantly associated with the abundance of Parabacteroides (p-value=2.92E-07). | [11] | |||
rs10486483 | |||||
HGF ID | HGF2543 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs10486483 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs2188962 | |||||
HGF ID | HGF2640 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs2188962 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs3197999 | |||||
HGF ID | HGF2627 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-MV) | |
Description | The rs3197999 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs17391694 | |||||
HGF ID | HGF2641 | HGF Info | Class | Single Nucleotide Polymorphism (SNP) | |
Description | The rs17391694 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs5763767 | |||||
HGF ID | HGF2642 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs5763767 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs12942547 | |||||
HGF ID | HGF2643 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs12942547 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs11230563 | |||||
HGF ID | HGF2644 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-MV) | |
Description | The rs11230563 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs1569328 | |||||
HGF ID | HGF2571 | HGF Info | Class | Single Nucleotide Polymorphism (SNP) | |
Description | The rs1569328 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
rs6667605 | |||||
HGF ID | HGF2621 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
Description | The rs6667605 SNP is associated with the abundance of Parabacteroides distasonis. | [12] | |||
Host Immune Factors (HIFs) | |||||
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B cells | |||||
HIF ID | HIFC0001 | HIF Info | Class | B cells (BCs) | |
Description | Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in B cells.. | [13] | |||
Cytotoxic T-lymphocyte-associated protein 4 | |||||
HIF ID | HIFM0068 | HIF Info | Class | Checkpoint molecule (CM) | |
Description | The abundance of Parabacteroides distasonis(of the Bacteroidales order) have been associated with response to CTLA-4 blockade in humans. | [14] | |||
Granulocyte colony-stimulating factor | |||||
HIF ID | HIFM0067 | HIF Info | Class | Cytokine (Cyt) | |
Description | Parabacteroides distasonis is associated with the expression of G-CSF. | [15] | |||
Interferon-10 | |||||
HIF ID | HIFM0128 | HIF Info | Class | Cytokine (Cyt) | |
Description | The increase production in IL-10 in the Parabacteroides distasonis colon from PBS-treated healthy mice. | [15] | |||
Interleukin-12 subunit beta | |||||
HIF ID | HIFM0131 | HIF Info | Class | Cytokine (Cyt) | |
Description | Parabacteroides distasonis is associated with interleukin (IL)-l12p40p70. | [15] | |||
Interferon-6 | |||||
HIF ID | HIFM0151 | HIF Info | Class | Cytokine (Cyt) | |
Description | Parabacteroides distasonis is associated with IL-6 expression. | [15] | |||
Transforming growth factor beta-2 proprotein | |||||
HIF ID | HIFM0213 | HIF Info | Class | Cytokine (Cyt) | |
Description | Parabacteroides distasonis is associated with TGF- concentrations. | [15] | |||
M1 macrophages | |||||
HIF ID | HIFC0019 | HIF Info | Class | Macrophages (Mac) | |
Description | Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in M1 macrophages.. | [13] | |||
CD4+ regulatory T cells | |||||
HIF ID | HIFC0034 | HIF Info | Class | T cells (TCs) | |
Description | Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in CD4+ T cells. | [13] | |||
CD4+CD25+FOXP3+ regulatory T cells | |||||
HIF ID | HIFC0036 | HIF Info | Class | T cells (TCs) | |
Description | Parabacteroides distasonis induced an increase in CD4+CD25+FoxP3+Treg cells. | [15] | |||
CD8+ T cells | |||||
HIF ID | HIFC0073 | HIF Info | Class | T cells (TCs) | |
Description | Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in CD8+ T cells. | [13] | |||
Splenocytes | |||||
HIF ID | HIFC0091 | HIF Info | Class | T cells (TCs) | |
Description | Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in splenocytes. | [13] | |||
CD103+Helios CD4+CD25+FOXP3+ regulatory T cells | |||||
HIF ID | HIFC0186 | HIF Info | Class | T cells (TCs) | |
Description | Bacteroides distasonis is related to the expansion of colonic CD103+HeliosCD4+CD25+FOXP3+ Treg cell population. | [16] | |||
Environmental Factor(s) | |||||
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Disbiome ID | |||||
gutMDisorder ID | |||||
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