Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01145)
MIC Name Saccharomyces cerevisiae (budding yeasts)
MIC Synonyms Mycoderma cerevisiae
Body Site Mucosa
Lineage Kingdom: Eukaryota
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Saccharomycetaceae
Genus: Saccharomyces
Species: Saccharomyces cerevisiae
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative
Host Relationship Probiotic
Description Saccharomyces cerevisiae is a facultative anaerobic fungi. More specifically, it is a globular-shaped, yellow-green yeast belonging to the Fungi kingdom.
External Links Taxonomy ID
4932
Genome Assembly ID
ASM308665v1
GOLD Organism ID
Go0019361
Disease Relevance
          Crohn disease  [ICD-11: DD70]
             Description Hypersensitivity was associated with Saccharomyces cerevisiae. [1]
Host Immune Factors (HIFs)
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Saccharomyces cerevisiae inhibited IL-1alpha transcript expression in non-differentiated IPEC-J2 cell line. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Saccharomyces cerevisiae decreased the ETEC-induced IL-6 secretions in IPEC-1 cells. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description At the species level, Saccharomyces cerevisiae did not decrease significantly the mRNA expressions of TNF-, IL-1, IL-5 and CXCL12 which were up-regulated by ETEC. [2]
          Immunoglobulin G3
             HIF ID HIFM0267 HIF Info       Class Immunoglobulin (Ig)
             Description IgG3 could be against Saccharomyces cerevisiae. [3]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description IgG2 could be against Saccharomyces cerevisiae. [3]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description IgG1 could be against Saccharomyces cerevisiae. [3]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Saccharomyces cerevisiae is associated with IgG response. [3]
          Immunoglobulin G4
             HIF ID HIFM0278 HIF Info       Class Immunoglobulin (Ig)
             Description IgG4 is associated with Saccharomyces cerevisiae. [3]
          Extracellular signal-regulated kinase 1 signaling pathway
             HIF ID HIFP0008 HIF Info       Class Signaling pathway (SP)
             Description Saccharomyces cerevisiae could inhibite ETEC-Mediated ERK1 Signaling Pathways. [2]
          Extracellular signal-regulated kinase 2 signaling pathway
             HIF ID HIFP0009 HIF Info       Class Signaling pathway (SP)
             Description Saccharomyces cerevisiae could inhibite ETEC-Mediated ERK2 Signaling Pathways. [2]
          P38 signaling pathway
             HIF ID HIFP0031 HIF Info       Class Signaling pathway (SP)
             Description Saccharomyces cerevisiae could inhibite ETEC-Mediated p38 Signaling Pathways. [2]
Environmental Factor(s)
             Disbiome ID
      941
References
1 Antibody to selected strains of Saccharomyces cerevisiae (baker's and brewer's yeast) and Candida albicans in Crohn's disease. Gut. 1990 May;31(5):536-8. doi: 10.1136/gut.31.5.536.
2 Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One. 2011 Apr 4;6(4):e18573. doi: 10.1371/journal.pone.0018573.
3 Anti-food and anti-microbial IgG subclass antibodies in inflammatory bowel disease.Scand J Gastroenterol. 2016 Dec;51(12):1453-1461. doi: 10.1080/00365521.2016.1205130. Epub 2016 Jul 25.

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