General Information of HIF (ID: HIFM0003)
HIF Name	Adrenomedullin
HIF Synonym(s)	AM
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Hormone
Description	Adrenomedullin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Calcitonin / CGRP / IAPP family (PF00214 )
Pathway	Neuroactive ligand-receptor interaction (hsa04080 )
	Vascular smooth muscle contraction (hsa04270 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	ADML_HUMAN
	APD ID	AP01477

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	Ultrastructural analyses have shown that treatment with Adrenomedullin(AM) causes a cell-wall disruption in Escherichia coli.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Adrenomedullin regulates intestinal physiology and pathophysiology.Domest Anim Endocrinol. 2016 Jul;56 Suppl:S66-83. doi: 10.1016/j.domaniend.2016.02.004.

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