General Information of HIF (ID: HIFM0042)
HIF Name	DNAX accessory molecule-1
HIF Synonym(s)	DNAM-1, CD226
HIF Classification	Checkpoint molecule (CM)
Molecular Function	Receptor
Description	DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors.				[1]
Pfam	Immunoglobulin V-set domain (PF07686 )
Pathway	Cell adhesion molecules (CAMs) (hsa04514 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CD226_HUMAN

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	The ectodomain of human CD226 (hCD226-ecto) was expressed in Escherichia coli cells as inclusion bodies.				[2]

References
1	Expression of CD226 is associated to but not required for NK cell education.Nat Commun. 2017 May 31;8:15627. doi: 10.1038/ncomms15627.
2	Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):988-996. doi: 10.1073/pnas.1815716116. Epub 2018 Dec 27.

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