General Information of HIF (ID: HIFM0043)
HIF Name	Natural killer cell receptor 2B4
HIF Synonym(s)	NAIL, NKR2B4, h2B4, SLAMF4, CD244, 2B4
HIF Classification	Checkpoint molecule (CM)
Molecular Function	Receptor
Description	2B4 is expressed on T cells to regulate responses to self-proteins.				[1]
Pfam	Immunoglobulin domain (PF13895 )
	Natural killer cell receptor 2B4 (PF11465 )
Pathway	Natural killer cell mediated cytotoxicity (hsa04650 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CD244_HUMAN

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	A single-chain Fv construct of the 2B4 T-cell receptor has been made and expressed in Escherichia coli as bacterial inclusion bodies.				[2]

References
1	Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2	A bacterially expressed single-chain Fv construct from the 2B4 T-cell receptor.Proc Natl Acad Sci U S A. 1993 May 1;90(9):3830-4. doi: 10.1073/pnas.90.9.3830.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.