Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0088)
HIF Name
Human defensin 5
HIF Synonym(s)
Human Defensin 5, HD-5, HD5, DEFA5
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Defensin; Fungicide
Description human defensin 5 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Defensin propeptide (PF00879 )
Mammalian defensin (PF00323 )
Pathway NOD-like receptor signaling pathway (hsa04621 )
Staphylococcus aureus infection (hsa05150 )
Transcriptional misregulation in cancer (hsa05202 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
DEF5_HUMAN
APD ID
AP00181
Microbe Species (MIC) Regulated by This HIF
         Salmonella sp. (enterobacteria) MIC01149
             Description HD5 conferred immunity against oral Salmonella infection by reducing bacterial numbers in the intestinal lumen. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Paneth cell -defensins and enteric microbiota in health and disease.Biosci Microbiota Food Health. 2016;35(2):57-67. doi: 10.12938/bmfh.2015-019. Epub 2015 Nov 26.

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