General Information of HIF (ID: HIFM0161)
HIF Name	Lymphocyte activation gene3
HIF Synonym(s)	LAG3, LAG-3
HIF Classification	Checkpoint molecule (CM)
Description	LAG3 is identified as crucial regulators of the immune response, which motivated the emergence of immune checkpointtargeting therapeutic strategie.				[1]
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	LAG3_HUMAN

Microbe Species (MIC) Regulated by This HIF
Salmonella sp. (enterobacteria)			MIC01149
Description	The elevated abundance of LAG-3+CD138hi cells correlates with impaired immunity against Salmonella.				[2]

References
1	Assessment of the expression of the immune checkpoint molecules PD-1, CTLA4, TIM-3 and LAG-3 across different cancers in relation to treatment response, tumor-infiltrating immune cells and survival.Int J Cancer. 2020 Jul 15;147(2):423-439. doi: 10.1002/ijc.32785. Epub 2019 Dec 2.
2	LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.Immunity. 2018 Jul 17;49(1):120-133.e9. doi: 10.1016/j.immuni.2018.06.007. Epub 2018 Jul 10.

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