General Information of HIF (ID: HIFM0187)
HIF Name	OX-2 membrane glycoprotein
HIF Synonym(s)	CD200
HIF Classification	Checkpoint molecule (CM)
Description	CD200 is a glycoprotein expressed on neurons and can promote protection through binding the microglial CD200 receptor (CD200R). CD200 belongs to the immunoglobulin superfamily and CD200 transmits an immunoregulatory signal through CD200R to limit microglial proinflammatory activity.				[1]
Pfam	Immunoglobulin domain (PF00047 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	OX2G_HUMAN

Microbe Species (MIC) Regulated by This HIF
Salmonella sp. (enterobacteria)			MIC01149
Description	LAG-3+CD138hi plasma cells which correlates with impaired immunity against Salmonella,can express the immune checkpoint receptors implicated in the negative regulation of immunity such as CD200.				[2]

References
1	Modulation of immune checkpoint molecule expression in mantle cell lymphoma.Leuk Lymphoma. 2019 Oct;60(10):2498-2507. doi: 10.1080/10428194.2019.1569231. Epub 2019 Mar 1.
2	LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.Immunity. 2018 Jul 17;49(1):120-133.e9. doi: 10.1016/j.immuni.2018.06.007. Epub 2018 Jul 10.

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