General Information of HIF (ID: HIFM0209)
HIF Name	Human alpha-synuclein
HIF Synonym(s)	Human Alpha-Synuclein, NACP
HIF Classification	Antimicrobial peptide (AMP)
Description	Human alpha-synuclein has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Synuclein (PF01387 )
Pathway	Alzheimer disease (hsa05010 )
	Parkinson disease (hsa05012 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	SYUA_HUMAN
	APD ID	AP02852

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	Colonization with curli-producing Escherichia coli can promote alpha-Syn pathology in the gut and the brain.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	A gut bacterial amyloid promotes -synuclein aggregation and motor impairment in mice.Elife. 2020 Feb 11;9:e53111. doi: 10.7554/eLife.53111.

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