Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0225)
HIF Name
Tumor necrosis factor ligand superfamily member 18
HIF Synonym(s)
GITR ligand, Glucocorticoid-induced TNF-related ligand, TNFSF18, AITRL, TL6, UNQ149/PRO175, GITRL
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Cytokine
Description GITRL is expressed on T cells to regulate responses to self-proteins. [1]
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNF18_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description The extracellular domain of human GITR ligand has been expressed and purified in Escherichia coli. [2]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states.Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5465-70. doi: 10.1073/pnas.0711350105. Epub 2008 Mar 31.

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