Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0230)
HIF Name
Tumor necrosis factor receptor superfamily member 18
HIF Synonym(s)
CD357, Glucocorticoid-induced TNFR-related protein, TNFRSF18, AITR, UNQ319/PRO364, GITR
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Receptor
Description GITR is expressed on T cells to regulate responses to self-proteins. [1]
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNR18_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description GITR contributes to the systemic adjuvanticity of the Escherichia coli heat-labile enterotoxin. [2]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 GITR contributes to the systemic adjuvanticity of the Escherichia coli heat-labile enterotoxin.Eur J Immunol. 2010 Mar;40(3):754-63. doi: 10.1002/eji.200939865.

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