General Information of HIF (ID: HIFM0247)
HIF Name	Toll-like receptor 21
HIF Synonym(s)	Toll-like receptor 21, TLR-21
HIF Classification	Toll-like receptor (TLR)
Description	Toll-like receptor 21 (TLR21) is a non-mammalian TLR recognizing unmethylated CpG DNA and considered as a functional homolog of mammalian TLR9				[1]

Microbe Species (MIC) Regulated by This HIF
Mycoplasma gallisepticum (mycoplasmas)			MIC00869
Description	TLR21 was decreased in expression in Mycoplasma gallisepticum Rlow-infected subjects.				[2]

References
1	Systemic immune responses to an inactivated, whole H9N2 avian influenza virus vaccine using class B CpG oligonucleotides in chickens.Vaccine. 2015 Jul 31;33(32):3947-52. doi: 10.1016/j.vaccine.2015.06.043. Epub 2015 Jun 16.
2	Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated Mycoplasma gallisepticum and Low-Pathogenic Avian Influenza A Virus in Chickens. Infect Immun. 2019 Dec 17;88(1):e00607-19. doi: 10.1128/IAI.00607-19. Print 2019 Dec 17.

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