Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0250)
HIF Name	Killer-cell immunoglobulin-like receptor
HIF Synonym(s)	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1, KIR3DL1, NKB1, NKAT3, NKB1B, NKAT-3, CD158E1, KIR2DL5B, KIR3DL1/S1
HIF Classification	MHC-I receptor (MHCIR)
Description	There are three major families of MHCI receptors found on NK cells including killer cell-immunoglobulin receptor (KIR), CD94/NKG2 and leukocyte immunoglobulin-like receptor (LILR) in humans.	[1]

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)		MIC00516
Description	Expression in Escherichia coli has been achieved by replacing three fourths of the transmembrane pore with the pore of a prokaryotic Kir channel.		[2]

References
1	Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders.Front Synaptic Neurosci. 2010 Sep 8;2:136. doi: 10.3389/fnsyn.2010.00136. eCollection 2010.
2	Crystal structure of a Kir3.1-prokaryotic Kir channel chimera.EMBO J. 2007 Sep 5;26(17):4005-15. doi: 10.1038/sj.emboj.7601828. Epub 2007 Aug 16.

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