Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0328)
HIF Name
SPINK9-v1
HIF Synonym(s)
Spink9-v1, serine peptidase inhibitor, Kazal type 9, variant 1
HIF Classification
Antimicrobial peptide (AMP)
Description SPINK9-v1 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
External Links
APD ID
AP03038
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description In the presence of 1% of tryptic soy broth (TSB), rSPINK9-v1 showed high killing activity against Escherichia coli; in contrast, without the presence of TSB, rSPINK9-v1 showed no killing activity. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Skin-Derived SPINK9 Kills Escherichia coli.J Invest Dermatol. 2019 May;139(5):1135-1142. doi: 10.1016/j.jid.2018.11.004. Epub 2018 Nov 20.

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