Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0005)
HIF Name	CAMP Responsive Element Binding Protein 1 signaling pathway
HIF Synonym(s)	CREB1 pathway, CREB1 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	The neuroplastic pathway, which includes cyclic adenosine monophosphate response element-binding protein 1 (CREB1), brain-derived neurotrophic factor (BDNF), and its receptor (neurotrophic tyrosine kinase receptor, type 2 [ NTRK2 ]), plays a crucial role in the adaptation of brain to stress, and thus variations of these genes are plausible risk factors for depression.	[1]

Microbe Species (MIC) Regulated by This HIF
Campylobacter concisus (epsilon-proteobacteria)		MIC00302
Description	Global profiling of the transcriptome revealed the significant regulation of a total of 8, 343 transcripts upon infection with Campylobacter concisus, which included the activation of key inflammatory pathways involving CREB1, NF-kappaB, STAT, and interferon regulatory factor signaling.		[2]

References
1	The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry. 2011 Apr 15;69(8):762-71. doi: 10.1016/j.biopsych.2010.11.019. Epub 2011 Jan 7.
2	Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus. Infect Immun. 2015 Feb;83(2):832-45. doi: 10.1128/IAI.03012-14. Epub 2014 Dec 8.

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