Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0037)
HIF Name	Signal transducer and activator of transcription signaling pathway
HIF Synonym(s)	Stat, STAT signaling pathway
HIF Classification	Signaling pathway (SP)
Description	The STAT signaling pathway transmits information from chemical signals outside the cell into gene promoters on the DNA in the cell nucleus, causing DNA transcription and activity in the cell.	[1]

Microbe Species (MIC) Regulated by This HIF
Campylobacter concisus (epsilon-proteobacteria)		MIC00302
Description	Global profiling of the transcriptome revealed the significant regulation of a total of 8, 343 transcripts upon infection with Campylobacter concisus, which included the activation of key inflammatory pathways involving CREB1, NF-kappaB, STAT, and interferon regulatory factor signaling.		[2]

References
1	JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.Drugs. 2017 Apr;77(5):521-546. doi: 10.1007/s40265-017-0701-9.
2	Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus. Infect Immun. 2015 Feb;83(2):832-45. doi: 10.1128/IAI.03012-14. Epub 2014 Dec 8.

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