Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00203)
MIC Name Bifidobacteriaceae (actinobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Description The Bifidobacteriaceae is the only family in the order Bifidobacteriales.
External Links Taxonomy ID
31953
Disease Relevance
          Parkinsonism  [ICD-11: 8A00]
             Description Bifidobacteriaceae was associated with parkinsons disease. [1]
Host Genetic Factors (HGFs)
          RNF115
             HGF ID HGF2315 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The gene RNF115 with exon duplications was significantly associated with decreased abundance of Bifidobacteriaceae. [2]
          rs748841
             HGF ID HGF1688 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs748841 SNP is significantly associated with the abundance of Bifidobacteriaceae (p-value=1.48E-04). [2]
          rs6719488
             HGF ID HGF1684 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs6719488 SNP is significantly associated with the abundance of Bifidobacteriaceae (p-value=1.98E-04). [2]
          rs651821
             HGF ID HGF1924 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description Each additional copy of the minor C allele at APOA5 SNP rs651821 decreased the abundances of the Bifidobacteriaceae. [3]
          rs309180
             HGF ID HGF1524 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs309180 SNP is significantly associated with the abundance of Bifidobacteriaceae (p-value=1.98E-04). [2]
          rs2236783
             HGF ID HGF1685 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2236783 SNP is significantly associated with the abundance of Bifidobacteriaceae (p-value=1.98E-04). [2]
          rs12988076
             HGF ID HGF1689 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12988076 SNP is significantly associated with the abundance of Bifidobacteriaceae (p-value=1.98E-04). [2]
Environmental Factor(s)
             Disbiome ID
      233
             gutMDisorder ID
      gm0102
References
1 Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord. 2017 May;32(5):739-749. doi: 10.1002/mds.26942. Epub 2017 Feb 14.
2 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
3 The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.Gut. 2017 Jun;66(6):1031-1038. doi: 10.1136/gutjnl-2015-311326. Epub 2016 Apr 6.

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