General Information of MIC (ID: MIC00213)
MIC Name	Bifidobacterium dentium (actinobacteria)
MIC Synonyms	Actinomyces eriksonii
Body Site	Oral Cavity
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Bifidobacteriales Family: Bifidobacteriaceae Genus: Bifidobacterium Species: Bifidobacterium dentium
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Commensal
Genome Size (bp)	2635669
Description	Bifidobacterium dentium is a species of bacteria in the genus Bifidobacterium, branched anaerobic bacteria from the Bifidobacteriaceae family. B. dentium is a source of anaerobic infections, and is also tracked in polluted water to trace the source of fecal contamination. Scientists have shown that B. dentium can cause tooth decay in humans. Due to its high tolerance of the acidic environments reached by the human mouth, B. dentium can sustain growth in the oral cavities, cause harm to the teeth, and break down sugars.
External Links	Taxonomy ID	1689
	Genome Assembly ID	ASM17213v1
	GOLD Organism ID	Go0001551
Disease Relevance
Atherosclerotic cardiovascular disease  [ICD-11: BA5Z]
Description	Bifidobacterium dentium was associated with genetic variants in Atherosclerotic cardiovascular disease.				[1]
Chronic hepatitis B  [ICD-11: 1E51]
Description	Bifidobacterium dentium was detected low frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls.				[2]
Coeliac disease  [ICD-11: DA95]
Description	Bacterial counts of Bifidobacterium dentium increased when the genetic risk of coeliac disease was increased.				[3]
Rheumatoid arthritis  [ICD-11: FA20]
Description	Bifidobacterium dentium was associated with genetic variants in Rheumatoid Arthritis.				[1]
Schizophrenia  [ICD-11: 6A20]
Description	Bifidobacterium dentium was associated with schizophrenia.				[4]
Type 2 diabetes mellitus  [ICD-11: 5A11]
Description	Bifidobacterium dentium was associated with genetic variants in Type 2 diabetes.				[1]

Host Genetic Factors (HGFs)
NXN
HGF ID	HGF2346	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of NXN has been associated with the amount of Bifidobacterium dentium.				[1]
rs651821
HGF ID	HGF1924	HGF Info	Class	Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
Description	The APOA5 SNP rs651821 might be an important host genetic factor in determining the abundances of the health-promoting Bifidobacterium bacteria and the taxa to which this genus belongs.				[5]

Environmental Factor(s)
Disbiome ID			40
gutMDisorder ID			gm0111

References
1	M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
2	Changes of fecal Bifidobacterium species in adult patients with hepatitis B virus-induced chronic liver disease. Microb Ecol. 2012 Feb;63(2):304-13. doi: 10.1007/s00248-011-9925-5. Epub 2011 Aug 4.
3	Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study. PLoS One. 2012;7(2):e30791. doi: 10.1371/journal.pone.0030791. Epub 2012 Feb 3.
4	The role of the gut microbiota in schizophrenia: Current and future perspectives. World J Biol Psychiatry. 2018 Dec;19(8):571-585. doi: 10.1080/15622975.2018.1433878. Epub 2018 Feb 21.
5	The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.Gut. 2017 Jun;66(6):1031-1038. doi: 10.1136/gutjnl-2015-311326. Epub 2016 Apr 6.

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