General Information of MIC (ID: MIC00539)
MIC Name	Enterobacterales (enterobacteria)
MIC Synonyms	Enterobacteriaceae and related endosymbionts; Enterobacteriaceae group
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales
Oxygen Sensitivity	Facultative anaerobe; Aerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Negative
Description	The Enterobacterales is an order of Gammaproteobacteria. They are aerobic but can be facultatively anaerobic, Gram-negative rods that are often found in vertebrate intestines.
External Links	Taxonomy ID	91347
Disease Relevance
Parkinsonism  [ICD-11: 8A00]
Description	Enterobacteriales increased in fecal samples of Parkinsons disease mice, along with increased fecal short-chain fatty acids (SCFAs).				[1]

Host Genetic Factors (HGFs)
rs35275482
HGF ID	HGF1573	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs35275482 SNP was significantly associated with the abundance of Enterobacteriales (p-value=3.72E-11).				[2]

Environmental Factor(s)
gutMDisorder ID			gm0285

References
1	Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF- signaling pathway. Brain Behav Immun. 2018 May;70:48-60. doi: 10.1016/j.bbi.2018.02.005. Epub 2018 Feb 20.
2	Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.

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