General Information of MIC (ID: MIC00755)
MIC Name	Lentisphaerae (bacteria)
MIC Synonyms	Lentisphaeraeota; Lentisphaerota
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Lentisphaerae
Oxygen Sensitivity	Aerobe or Anaerobe
Microbial Metabolism	Fermentative
Gram	Negative
Host Relationship	Commensal
Description	Lentisphaerae is a phylum of Gram negative bacteria closely related to Chlamydiae and Verrucomicrobia.
External Links	Taxonomy ID	256845
Disease Relevance
Juvenile idiopathic arthritis  [ICD-11: FA24]
Description	Lentisphaerae was associated with juvenile idiopathic arthritis.				[1]
Post traumatic stress disorder  [ICD-11: 6B40]
Description	Decreased total abundance of Actinobacteria, Lentisphaerae, and Verrucomicrobia was associated with PTSD status.				[2]

Host Genetic Factors (HGFs)
rs9541094
HGF ID	HGF2215	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs9541094 SNP was significantly associated with the relative abundance of Lentisphaerae (p-value=3.07E-08).				[3]
rs74997447
HGF ID	HGF1933	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs74997447 SNP was significantly associated with the relative abundance of Lentisphaerae (p-value=4.68E-09).				[3]
rs516246
HGF ID	HGF1582	HGF Info	Class	Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
Description	The rs516246 SNP was significantly associated with the abundance of Lentisphaerae (p-value=0.0266).				[4]
rs1800694
HGF ID	HGF1761	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs1800694 SNP was significantly associated with the relative abundance of Lentisphaerae (p-value=5.93E-08).				[3]
rs111870934
HGF ID	HGF1554	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs111870934 SNP was significantly associated with the relative abundance of Lentisphaerae (p-value=5.32E-11).				[3]

Environmental Factor(s)
gutMDisorder ID			gm0420

References
1	Faecal microbiome in new-onset juvenile idiopathic arthritis. Eur J Clin Microbiol Infect Dis. 2016 Mar;35(3):363-70. doi: 10.1007/s10096-015-2548-x. Epub 2015 Dec 30.
2	The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls: An Exploratory Study. Psychosom Med. 2017 Oct;79(8):936-946. doi: 10.1097/PSY.0000000000000512.
3	Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
4	FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.