Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00834)
MIC Name Mogibacterium timidum (firmicutes)
MIC Synonyms Eubacterium timidum
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiales Family XIII. Incertae Sedis
Genus: Mogibacterium
Species: Mogibacterium timidum
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Asaccharolytic
Gram Positive
Description The species Mogibacterium timidum (formerly Eubacterium timidum) is an obligately anaerobic, non-spore forming, gram-positive bacterium. M. timidum has shown not only an increase by up to 4.8x in subgingival tissue of chronic periodontitis suffers, yet hosts also have increased serum Immunoglobulin A levels produced in the case of adult refractory periodontitis.
External Links Taxonomy ID
35519
Genome Assembly ID
MtimATCC33093v1.0
GOLD Organism ID
Go0005415
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Periradicular disease was associated with Mogibacterium timidum. [1]
Host Genetic Factors (HGFs)
          RAG2
             HGF ID HGF2357 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of Rag2 could increase the abundance of Bifidobacteriales. [2]
          rs55987656
             HGF ID HGF1481 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs55987656 SNP was significantly associated with the relative abundance of Mogibacterium (p-value=6.33E-07). [3]
Environmental Factor(s)
             Disbiome ID
      704
             gutMDisorder ID
      gm0454
References
1 Detection of Slackia exigua, Mogibacterium timidum and Eubacterium saphenum from pulpal and periradicular samples using the Polymerase Chain Reaction (PCR) method. Int Endod J. 2001 Sep;34(6):463-70. doi: 10.1046/j.1365-2591.2001.00419.x.
2 Complementarity and redundancy of IL-22-producing innate lymphoid cells.Nat Immunol. 2016 Feb;17(2):179-86. doi: 10.1038/ni.3332. Epub 2015 Nov 30.
3 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.

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