Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01015)
MIC Name Prevotella intermedia (CFB bacteria)
MIC Synonyms Bacteroides melaninogenicus subsp. intermedius
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella intermedia
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2737273
No. of Coding Genes 2510
No. of Non-Coding Genes 61
No. of Small Non-Coding Genes 61
No. of Gene Transcripts 2571
No. of Base Pairs 2737273
Description Prevotella intermedia is an obligately anaerobic, Gram-negative, pathogenic bacterium involved in periodontal infections, including gingivitis and periodontitis, and often found in acute necrotizing ulcerative gingivitis. It is commonly isolated from dental abscesses, where obligate anaerobes predominate.
External Links Taxonomy ID
28131
Genome Assembly ID
ASM154819v1
GOLD Organism ID
Go0001782
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Prevotella intermedia was associated with periodontal disease. [1]
Host Genetic Factors (HGFs)
          rs419598
             HGF ID HGF1727 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The polymorphic expression of IL-1RN rs419598 gene may be associated with a decreased load of Prevotella intermedia. [2]
          rs1800587
             HGF ID HGF1729 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The SNP-889 rs1800587 in IL-1A gene was associated with a significant increase in Prevotella intermedia load. [2]
          rs12917993
             HGF ID HGF1852 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12917993 SNP was significantly associated with the abundance of Prevotella intermedia (p-value<1.00E-08). [3]
Environmental Factor(s)
             Disbiome ID
      355
             gutMDisorder ID
      gm0535
References
1 Population-Genomic Insights into Variation in Prevotella intermedia and Prevotella nigrescens Isolates and Its Association with Periodontal Disease. Front Cell Infect Microbiol. 2017 Sep 21;7:409. doi: 10.3389/fcimb.2017.00409. eCollection 2017.
2 Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.PLoS One. 2017 Oct 12;12(10):e0186366. doi: 10.1371/journal.pone.0186366. eCollection 2017.
3 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.

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