Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01119)
MIC Name Roseburia inulinivorans (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia inulinivorans
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Convert acetate
Gram Negative
Host Relationship Commensal
Genome Size (bp) 3781127
No. of Coding Genes 3442
No. of Non-Coding Genes 64
No. of Small Non-Coding Genes 64
No. of Gene Transcripts 3506
No. of Base Pairs 3781127
Description Roseburia inulinivorans is a bacterium first isolated from human faeces. It is anaerobic, Gram-positive or Gram-variable, slightly curved rod-shaped and motile.
External Links Taxonomy ID
360807
Genome Assembly ID
RIL183
GOLD Organism ID
Go0003376
Disease Relevance
          Crohn disease  [ICD-11: DD70]
             Description The abundance of Roseburia inulinivorans was low in C-reactive protein (CRP)-positive CD(Crohns disease) patients. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Roseburia inulinivorans was associated with inflammatory bowel disease. [2]
Host Genetic Factors (HGFs)
          15q11-13
             HGF ID HGF2318 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description There has a significantly different abundance of Roseburia inulinivorans between 15q dup mice and wide type littermates (p-value=0.03002). [3]
Environmental Factor(s)
             Disbiome ID
      58
             gutMDisorder ID
      gm0575
References
1 Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. Digestion. 2016;93(1):59-65. doi: 10.1159/000441768. Epub 2016 Jan 14.
2 Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases. Cell Host Microbe. 2017 May 10;21(5):603-610.e3. doi: 10.1016/j.chom.2017.04.010.
3 Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.

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