Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01254)
MIC Name Streptococcus infantis (firmicutes)
Body Site Nose
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus infantis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 1884302
No. of Coding Genes 1900
No. of Non-Coding Genes 62
No. of Small Non-Coding Genes 62
No. of Gene Transcripts 1962
No. of Base Pairs 2024688
Description Streptococcus infantis is a facultative anaerobic, Gram positive bacterium. It is a member of the commensal microbiota of the upper respiratory tract.
External Links Taxonomy ID
68892
Genome Assembly ID
ASM96325v1
GOLD Organism ID
Go0005316
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Streptococcus infantis is upregulated in disease expression of primary sclerosing cholangitis. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Streptococcus infantis is upregulated in inflammatory bowel disease. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description Streptococcus infantis was associated with ulcerative colitis. [1]
Host Genetic Factors (HGFs)
          rs4981353
             HGF ID HGF1487 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4981353 SNP is significantly associated with the abundance of Streptococcus infantis (p-value<1.00E-08). [2]
          rs2066842
             HGF ID HGF1456 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant gene NOD2 of innate immunity rs2066842 is significantly associated with the abundance of gut micriobiota Streptococcus infantis (p-value=0.0006). [3]
          rs1250546
             HGF ID HGF2565 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1250546 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs559928
             HGF ID HGF2652 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs559928 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs1819333
             HGF ID HGF2529 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1819333 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs1042058
             HGF ID HGF2617 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs1042058 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs4845604
             HGF ID HGF2573 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4845604 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs483905
             HGF ID HGF2599 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs483905 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs7240004
             HGF ID HGF2653 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7240004 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs17780256
             HGF ID HGF2654 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-PV)
             Description The rs17780256 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs7746082
             HGF ID HGF2649 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7746082 SNP is associated with the abundance of Streptococcus infantis. [4]
          rs1517352
             HGF ID HGF2547 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1517352 SNP is associated with the abundance of Streptococcus infantis. [4]
Environmental Factor(s)
             Disbiome ID
      929
             gutMDisorder ID
      gm0624
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.