General Information of MIC (ID: MIC01932)
MIC Name	Lactonifactor (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae Genus: Lactonifactor
Oxygen Sensitivity	Strictly anaerobe
Microbial Metabolism	Fermentative
Gram	Positive
Description	Bacteria of the genus Lactonifactor form Gram-positive rods. They are mesophilic, strictly anaerobic, catalase and indole negative. Spore formation and motility have not been observed.
External Links	Taxonomy ID	420345
	GOLD Organism ID	Go0546698

Host Genetic Factors (HGFs)
MIR21
HGF ID	HGF2332	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of MIR-21 was significantly increased the proportion of Lactonifactor (p-value<0.05).				[1]
rs47611520
HGF ID	HGF2591	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs47611520 SNP is associated with the heritable variation in Lactonifactor.				[2]
rs3661776
HGF ID	HGF2592	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs3661776 SNP is associated with the heritable variation in Lactonifactor.				[2]
rs6176297
HGF ID	HGF2593	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs6176297 SNP is associated with the heritable variation in Lactonifactor.				[2]

Environmental Factor(s)
Disbiome ID			229
gutMDisorder ID			gm0417

References
1	Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
2	Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 2014 Dec 2;6(12):107. doi: 10.1186/s13073-014-0107-1. eCollection 2014.

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