Drug Information

Drug General Information
Drug ID
D00DEF
Former ID
DAP000571
Drug Name
Lisdexamfetamine
Synonyms
NRP104; Lisdexamfetamine (INN); Vyvanse (TN)
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Approved [538579], [542228]
Company
New River Pharmaceuticals
Formula
C15H25N3O
InChI
InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1
InChIKey
VOBHXZCDAVEXEY-JSGCOSHPSA-N
CAS Number
CAS 608137-32-2
PubChem Compound ID
11597698
PubChem Substance ID
16843305, 23710324, 42764532, 46505358, 50070913, 78572726, 96024820, 126651840, 135195272, 136939966, 137001224, 137228331, 140917534, 160964587, 175265708, 178103788, 179150769, 224607397, 226522546, 244397481
SuperDrug ATC ID
N06BA12
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Modulator [529282], [531678]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 538579FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021977.
Ref 542228(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7213).
Ref 5292822007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
Ref 531678Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorg Med Chem. 2011 Dec 1;19(23):7044-8.

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