Drug Information

Drug General Information
Drug ID
D01BUT
Former ID
DIB007389
Drug Name
LXT-101
Synonyms
DepoLXT-101; GnRH antagonist (sustained release, prostate cancer), Beijing Institute of Pharmacology and Toxicology
Indication Prostate cancer [ICD9: 185; ICD10:C61] Investigative [528301]
Company
Beijing Institute of Pharmacology and Toxicology
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [528301]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528301Regul Pept. 2006 Sep 11;136(1-3):122-9. Epub 2006 Jul 10.In vivo characterization of a novel GnRH (gonadotropin-releasing hormone) antagonist, LXT-101, in normal male rats.
Ref 528301Regul Pept. 2006 Sep 11;136(1-3):122-9. Epub 2006 Jul 10.In vivo characterization of a novel GnRH (gonadotropin-releasing hormone) antagonist, LXT-101, in normal male rats.

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