Drug Information

Drug General Information
Drug ID
D01GEB
Former ID
DNC012867
Drug Name
ROXINDOLE
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [468254], [534084]
Formula
C23H26N2O
InChI
InChI=1S/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2
InChIKey
HGEYJZMMUGWEOT-UHFFFAOYSA-N
CAS Number
CAS 112192-04-8
PubChem Compound ID
219050
PubChem Substance ID
6349747, 9374254, 11114137, 14900636, 30422424, 47583771, 48329099, 49658794, 50916746, 85209757, 103266733, 103847333, 103916479, 113468488, 117617076, 124887037, 127339809, 127339810, 127339811, 128056374, 134222300, 134350072, 135141432, 135650930, 137248627, 142950049, 144204506, 162223603, 170466119, 179149560, 198986031, 223536057, 226433363
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [527191]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 468254(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 52).
Ref 534084Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996 Jan;276(1):41-8.
Ref 527191J Med Chem. 2004 Sep 9;47(19):4677-83.Indolebutylamines as selective 5-HT(1A) agonists.

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