Drug Information

Drug General Information
Drug ID
D01WQQ
Former ID
DIB005757
Drug Name
ABT-981
Drug Type
Monoclonal antibody
Indication Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] Phase 2 [889392], [889410]
Company
AbbVie
Target and Pathway
Target(s) Interleukin-1 alpha ligand Target Info Modulator [533176]
Interleukin-1 beta Target Info Modulator [533176]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
Apoptosis
Osteoclast differentiation
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Prion diseases
Salmonella infection
Pertussis
Leishmaniasis
Tuberculosis
Measles
Influenza A
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Graft-versus-host diseasehsa04010:MAPK signaling pathway
NF-kappa B signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
TNF signaling pathway
Inflammatory mediator regulation of TRP channels
Alzheimer's disease
Legionellosis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Amoebiasis
Herpes simplex infection
Graft-versus-host disease
NetPath Pathway IL5 Signaling Pathway
IL1 Signaling Pathway
TCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
IL2 Signaling Pathway
IL3 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL1-mediated signaling events
Validated transcriptional targets of deltaNp63 isoforms
a6b1 and a6b4 Integrin signalingil27pathway:IL27-mediated signaling events
IL12-mediated signaling events
IFN-gamma pathway
IL23-mediated signaling events
Cellular roles of Anthrax toxin
Reactome Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 signaling
Interleukin-1 processingR-HSA-446652:Interleukin-1 signaling
Interleukin-1 processing
CLEC7A/inflammasome pathway
WikiPathways SIDS Susceptibility Pathways
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Cytokines and Inflammatory Response
Hypertrophy Model
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Hematopoietic Stem Cell Differentiation
Structural Pathway of Interleukin 1 (IL-1)
Spinal Cord Injury
Allograft Rejection
IL-1 signaling pathway
Interleukin-1 signalingWP75:Toll-like receptor signaling pathway
Monoamine Transport
Type II interferon signaling (IFNG)
Myometrial Relaxation and Contraction Pathways
Aryl Hydrocarbon Receptor Pathway
IL1 and megakaryotyces in obesity
Alzheimers Disease
Leptin signaling pathway
Interleukin-1 signaling
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
Serotonin Transporter Activity
Regulation of toll-like receptor signaling pathway
NOD pathway
References
Ref 889392ClinicalTrials.gov (NCT02087904) A Phase 2a Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis
Ref 889410ClinicalTrials.gov (NCT02384538) A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis
Ref 533176Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. MAbs. 2015;7(3):605-19.

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