TTD | Drug: D01YWE

Drug General Information
Drug ID	D01YWE
Former ID	DIB019450
Drug Name	compound 33
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530078]
Formula	C17H14N4O4
InChI	InChI=1S/C17H14N4O4/c18-17(25)12(9-2-1-3-11(22)8-9)21-14-13(15(23)16(14)24)20-10-4-6-19-7-5-10/h1-8,12,21-22H,(H2,18,25)(H,19,20)
InChIKey	GPXKVULNYYNGDP-UHFFFAOYSA-N
PubChem Compound ID	25207521
PubChem Substance ID	57414577, 85045028, 103615908, 104109826, 230303564, 243036885, 249565843
Target and Pathway
Target(s)	Protein kinase A	Target Info	Inhibitor	[530078]
	Serine/threonine-protein kinase Chk1	Target Info	Inhibitor	[530078]
	Rho-associated protein kinase 1	Target Info	Inhibitor	[530078]
	casein kinase 1, gamma 1	Target Info	Inhibitor	[530078]
	ribosomal protein S6 kinase, 90kDa, polypeptide 1	Target Info	Inhibitor	[530078]
	MAPKAP kinase 2	Target Info	Inhibitor	[530078]
KEGG Pathway	Cell cycle
	p53 signaling pathway
	HTLV-I infection
	Viral carcinogenesishsa04022:cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	Sphingolipid signaling pathway
	Vascular smooth muscle contraction
	TGF-beta signaling pathway
	Axon guidance
	Focal adhesion
	Platelet activation
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Oxytocin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Salmonella infection
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancerhsa04010:MAPK signaling pathway
	VEGF signaling pathway
	Neurotrophin signaling pathway
	Viral carcinogenesis
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Cytoskeletal regulation by Rho GTPase
	Inflammation mediated by chemokine and cytokine signaling pathway
	CCKR signaling map STP00005:Angiogenesis
	Interleukin signaling pathway
	PDGF signaling pathway
	VEGF signaling pathway
	Ras Pathway
	p38 MAPK pathway
Pathway Interaction Database	Fanconi anemia pathway
	p73 transcription factor network
	ATR signaling pathway
	Circadian rhythm pathway
	p53 pathwayprlsignalingeventspathway:Signaling events mediated by PRL
	RhoA signaling pathway
	Noncanonical Wnt signaling pathway
	EPHB forward signaling
	Thromboxane A2 receptor signaling
	PAR4-mediated thrombin signaling events
	amb2 Integrin signaling
	Integrins in angiogenesis
	EPHA forward signaling
	Stabilization and expansion of the E-cadherin adherens junction
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
	N-cadherin signaling eventsil2_1pathway:IL2-mediated signaling events
	p38 signaling mediated by MAPKAP kinases
	Signaling mediated by p38-alpha and p38-beta
	Trk receptor signaling mediated by the MAPK pathway
Reactome	Activation of ATR in response to replication stress
	Processing of DNA double-strand break ends
	Presynaptic phase of homologous DNA pairing and strand exchange
	G2/M DNA damage checkpoint
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-111465:Apoptotic cleavage of cellular proteins
	EPHB-mediated forward signaling
	EPHA-mediated growth cone collapse
	G alpha (12/13) signalling events
	Sema4D induced cell migration and growth-cone collapse
	VEGFA-VEGFR2 Pathway
	RHO GTPases Activate ROCKsR-HSA-171007:p38MAPK events
	Oxidative Stress Induced Senescence
	Regulation of HSF1-mediated heat shock response
	activated TAK1 mediates p38 MAPK activation
WikiPathways	DNA Damage Response
	Signaling by SCF-KIT
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Cell Cycle
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP524:G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	EGF/EGFR Signaling Pathway
	TGF beta Signaling Pathway
	Focal Adhesion
	JAK/STAT
	AGE/RAGE pathway
	Pathogenic Escherichia coli infection
	Regulation of Microtubule Cytoskeleton
	Leptin signaling pathway
	Semaphorin interactions
	Integrin-mediated Cell Adhesion
	GPCR downstream signaling
	Apoptotic execution phase
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Serotonin HTR1 Group and FOS Pathway
	p38 MAPK Signaling Pathway
	MAPK Signaling Pathway
	FAS pathway and Stress induction of HSP regulation
	MAP kinase activation in TLR cascade
	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Arachidonic acid metabolism
	Structural Pathway of Interleukin 1 (IL-1)
	IL-1 signaling pathway
	NGF signalling via TRKA from the plasma membrane
	MAPK targets/ Nuclear events mediated by MAP kinases
References
Ref 530078	Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51.
Ref 530078	Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51.

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Drug Information