TTD | Drug: D03BJF

Drug General Information
Drug ID	D03BJF
Former ID	DIB019280
Drug Name	compound 17d
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[532095]
Formula	C25H34N6O2
InChI	InChI=1S/C25H34N6O2/c32-24(19-3-1-4-19)27-12-2-11-26-23-22(18-5-6-18)17-28-25(30-23)29-20-7-9-21(10-8-20)31-13-15-33-16-14-31/h7-10,17-19H,1-6,11-16H2,(H,27,32)(H2,26,28,29,30)
InChIKey	CJPMSUUANYLPET-UHFFFAOYSA-N
PubChem Compound ID	44465558
PubChem Substance ID	85745013, 97091160, 140600805, 163332792, 163350924, 238428524, 243098881, 249565876
Target and Pathway
Target(s)	MARK3	Target Info	Inhibitor	[532095]
	Inhibitor of nuclear factor kappa-B kinase	Target Info	Inhibitor	[532095]
	Mitogen-activated protein kinase kinase kinase 7	Target Info	Inhibitor	[532095]
	TANK-binding kinase 1	Target Info	Inhibitor	[532095]
NetPath Pathway	IL5 Signaling Pathway
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	TGF-beta signaling pathway
	Toll receptor signaling pathway
	Wnt signaling pathway
	p38 MAPK pathway
Pathway Interaction Database	BCR signaling pathway
	p38 MAPK signaling pathway
	Noncanonical Wnt signaling pathway
	Presenilin action in Notch and Wnt signaling
	IL1-mediated signaling events
	TNF receptor signaling pathway
	BMP receptor signaling
	JNK signaling in the CD4+ TCR pathway
	C-MYB transcription factor network
	Ephrin B reverse signaling
	TGF-beta receptor signaling
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	RAF activation
	MAP2K and MAPK activation
	Negative regulation of MAPK pathwayR-HSA-1169091:Activation of NF-kappaB in B cells
	NOD1/2 Signaling Pathway
	RIP-mediated NFkB activation via ZBP1
	AKT phosphorylates targets in the cytosol
	p75NTR recruits signalling complexes
	NF-kB is activated and signals survival
	FCERI mediated NF-kB activation
	Interleukin-1 signaling
	Regulation of TNFR1 signaling
	TNFR1-induced NFkappaB signaling pathway
	IKBKB deficiency causes SCID
	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
	IkBA variant leads to EDA-ID
	Dectin-1 mediated noncanonical NF-kB signaling
	CLEC7A (Dectin-1) signaling
	Constitutive Signaling by AKT1 E17K in Cancer
	NIK-->noncanonical NF-kB signaling
	MAP3K8 (TPL2)-dependent MAPK1/3 activation
	TRAF6 mediated IRF7 activation
	TRAF6 mediated NF-kB activation
	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
	Negative regulators of RIG-I/MDA5 signaling
	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
	IRAK1 recruits IKK complex
	IKK complex recruitment mediated by RIP1
	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationR-HSA-1169091:Activation of NF-kappaB in B cells
	Ca2+ pathway
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	activated TAK1 mediates p38 MAPK activation
	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
	TRAF6 mediated induction of TAK1 complex
WikiPathways	Toll-like receptor signaling pathway
	Estrogen signaling pathway
	TCR Signaling Pathway
	Insulin Signaling
	IL-4 Signaling Pathway
	MAPK Signaling Pathway
	NLR Proteins
	Hair Follicle Development: Induction (Part 1 of 3)
	MyD88 cascade initiated on plasma membrane
	Cardiac Hypertrophic Response
	Cytosolic sensors of pathogen-associated DNA
	MyD88 dependent cascade initiated on endosome
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
	MyD88:Mal cascade initiated on plasma membrane
	Fc epsilon receptor (FCERI) signaling
	MyD88-independent cascade
	Signaling by the B Cell Receptor (BCR)
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Structural Pathway of Interleukin 1 (IL-1)
	EBV LMP1 signaling
	Polycystic Kidney Disease Pathway
	Apoptosis
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	BDNF signaling pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TNF alpha Signaling Pathway
	B Cell Receptor Signaling Pathway
	IL17 signaling pathway
	TWEAK Signaling Pathway
	Leptin signaling pathway
	RANKL/RANK Signaling Pathway
	Signalling by NGF
	IL-1 signaling pathway
	TCR signaling
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Interleukin-1 signaling
	Apoptosis Modulation and Signaling
	Type II diabetes mellitus
	MicroRNAs in cardiomyocyte hypertrophy
	Regulation of toll-like receptor signaling pathway
	Osteopontin Signaling
	NOD pathwayWP75:Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	p38 MAPK Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	TGF beta Signaling Pathway
	IL-6 signaling pathway
	FAS pathway and Stress induction of HSP regulation
	MAP kinase activation in TLR cascade
References
Ref 532095	Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.
Ref 532095	Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.

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Drug Information