Drug Information

Drug General Information
Drug ID
D03ZYX
Former ID
DNC011961
Drug Name
N-hydroxyglycine derivative
Indication Discovery agent Investigative [551333]
Target and Pathway
Target(s) Squalene synthetase Target Info Inhibitor [551333]
BioCyc Pathway Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Cholesterol biosynthesis III (via desmosterol)
Cholesterol biosynthesis I
Superpathway of cholesterol biosynthesis
Epoxysqualene biosynthesis
KEGG Pathway Steroid biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
Cholesterol biosynthesis
References
Ref 551333N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase, Bioorg. Med. Chem. Lett. 7(23):3039-3044 (1997).
Ref 551333N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase, Bioorg. Med. Chem. Lett. 7(23):3039-3044 (1997).

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