Drug Information

Drug General Information
Drug ID
D06YFO
Former ID
DIB008897
Drug Name
AD-121
Synonyms
PW-9101; Rheumatoid arthritis therapeutic (oral controlled release, Syncrodose), Arakis/Penwest; Rheumatoid arthritis therapeutic (oral controlled release, TIMERx), Arakis/Penwest
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Discontinued in Phase 1/2 [547307]
Company
Sosei R&D Ltd
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Modulator [543900]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 547307Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015041)
Ref 543900(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622).

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