Drug Information

Drug General Information
Drug ID
D07EHV
Former ID
DIB011733
Drug Name
LGH-447
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Phase 1/2 [524766]
Company
Novartis
Target and Pathway
Target(s) Serine/threonine-proteinkinase pim-2 Target Info Modulator [532650]
KEGG Pathway Acute myeloid leukemia
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
WikiPathways Hematopoietic Stem Cell Differentiation
References
Ref 524766ClinicalTrials.gov (NCT02144038) Study of the Safety and Effectiveness of LGH447 and BYL719 in Patients With Relapsed and Refractory Multiple Myeloma. U.S. National Institutes of Health.
Ref 532650Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.

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