Drug Information

Drug General Information
Drug ID
D08KQM
Former ID
DNC008423
Drug Name
LGD-5552
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529166]
Formula
C28H26FNO3
Canonical SMILES
CC1=CC=CC(=C1F)C=C2C3=C(C=CC4=C3C(=CC(N4)(C)C)C)C5=C(O2<br />)C=CC(=C5OC)O
InChI
1S/C28H26FNO3/c1-15-7-6-8-17(26(15)29)13-22-24-18(25-21(33-22)12-11-20(31)27(25)32-5)9-10-19-23(24)16(2)14-28(3,4)30-19/h6-14,30-31H,1-5H3/b22-13-
InChIKey
ACYYHAZVNHMRMQ-XKZIYDEJSA-N
PubChem Compound ID
24816375
Target and Pathway
Target(s) mRNA of androgen receptor Target Info Inhibitor [529166]
mRNA of glucocorticoid receptor Target Info Inhibitor [529166]
Progesterone receptor Target Info Inhibitor [529166]
Mineralocorticoid receptor Target Info Inhibitor [529166]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04080:Neuroactive ligand-receptor interactionhsa04114:Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04960:Aldosterone-regulated sodium reabsorption
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
AP-1 transcription factor networkanthraxpathway:Cellular roles of Anthrax toxin
PathWhiz Pathway Kidney Function
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-1251985:Nuclear signaling by ERBB4
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear ReceptorsWP34:Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP554:ACE Inhibitor Pathway
References
Ref 529166Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. Epub 2007 Nov 21.Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.
Ref 529166Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. Epub 2007 Nov 21.Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.