Drug Information

Drug General Information
Drug ID
D08RJC
Former ID
DNC004169
Drug Name
PD-32577
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525576]
Formula
C29H42N2O2
Canonical SMILES
CC(C)(C1=CC(=C(C=C1)O)CN2CCCCCC2)C3=CC(=C(C=C3)O)CN4CCC<br />CCC4
InChI
1S/C29H42N2O2/c1-29(2,25-11-13-27(32)23(19-25)21-30-15-7-3-4-8-16-30)26-12-14-28(33)24(20-26)22-31-17-9-5-6-10-18-31/h11-14,19-20,32-33H,3-10,15-18,21-22H2,1-2H3
InChIKey
GHZGEEOGCPBASL-UHFFFAOYSA-N
PubChem Compound ID
44460434
Target and Pathway
Target(s) Voltage-dependent N-type calcium channel Target Info Inhibitor [525576]
Voltage-dependent L-type calcium channel subunit alpha-1C Target Info Inhibitor [525576]
Potassium voltage-gated channel subfamily KQT member 3 Target Info Inhibitor [525576]
Potassium voltage-gated channel subfamily KQT member 2 Target Info Inhibitor [525576]
PN3 Na+ channel Target Info Inhibitor [525576]
Voltage-dependent L-type calcium channel alpha-1D subunit Target Info Inhibitor [525576]
Voltage-gated sodium channel subunit alpha Nav1.9 Target Info Inhibitor [525576]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addictionhsa04010:MAPK signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Insulin secretion
GnRH signaling pathway
Oxytocin signaling pathway
Alzheimer's disease
Amphetamine addiction
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04725:Cholinergic synapsehsa04725:Cholinergic synapsehsa04010:MAPK signaling pathway
Carbohydrate digestion and absorption
Dilated cardiomyopathy
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signalingP00003:Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
5HT2 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Oxytocin receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium ChannelsR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretionR-HSA-1296072:Voltage gated Potassium channels
Interaction between L1 and AnkyrinsR-HSA-1296072:Voltage gated Potassium channels
Interaction between L1 and AnkyrinsR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
Regulation of insulin secretionR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle PathwayWP536:Calcium Regulation in the Cardiac Cell
Arrhythmogenic Right Ventricular Cardiomyopathy
Alzheimers Disease
NCAM signaling for neurite out-growth
Integration of energy metabolism
Nicotine Activity on Chromaffin CellsWP2669:Potassium Channels
L1CAM interactionsWP2669:Potassium Channels
L1CAM interactionsWP536:Calcium Regulation in the Cardiac Cell
References
Ref 525576Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.
Ref 525576Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.

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