TTD | Drug: D09WPN

Drug General Information
Drug ID	D09WPN
Former ID	DNC000235
Drug Name	AP22408
Drug Type	Small molecular drug
Indication	Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890]		Terminated	[546858]
Formula	C30H41N3O10P2
Canonical SMILES	CC(=O)NC(CC1=CC(=C(C=C1)P(=O)(O)O)P(=O)(O)O)C(=O)NC2CCC<br />CC3=C2C=C(C(=C3)OCC4CCCCC4)C(=O)N
InChI	1S/C30H41N3O10P2/c1-18(34)32-25(13-20-11-12-27(44(37,38)39)28(14-20)45(40,41)42)30(36)33-24-10-6-5-9-21-15-26(23(29(31)35)16-22(21)24)43-17-19-7-3-2-4-8-19/h11-12,14-16,19,24-25H,2-10,13,17H2,1H3,(H2,31,35)(H,32,34)(H,33,36)(H2,37,38,39)(H2,40,41,42)/t24-,25-/m0/s1
InChIKey	SPSGYTWOIGAABK-DQEYMECFSA-N
CAS Number	CAS 268741-43-1
PubChem Compound ID	445561
PubChem Substance ID	838981, 7886503, 10299723, 36888239, 74852898, 104634572, 129270910, 134339713, 172649879, 198935679, 232882700
Target and Pathway
Target(s)	Proto-oncogene tyrosine-protein kinase SRC	Target Info	Inhibitor	[535031]
KEGG Pathway	ErbB signaling pathway
	Rap1 signaling pathway
	Chemokine signaling pathway
	Endocytosis
	VEGF signaling pathway
	Focal adhesion
	Adherens junction
	Tight junction
	Gap junction
	Platelet activation
	GABAergic synapse
	Inflammatory mediator regulation of TRP channels
	Regulation of actin cytoskeleton
	GnRH signaling pathway
	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Bacterial invasion of epithelial cells
	Epithelial cell signaling in Helicobacter pylori infection
	Shigellosis
	Tuberculosis
	Hepatitis B
	Viral carcinogenesis
	Proteoglycans in cancer
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	Cadherin signaling pathway
	Integrin signalling pathway
	Parkinson disease
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	Signaling events mediated by PRL
	LPA receptor mediated events
	Atypical NF-kappaB pathway
	Glypican 1 network
	Plasma membrane estrogen receptor signaling
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Signaling events mediated by PTP1B
	S1P3 pathway
	EPHB forward signaling
	Nectin adhesion pathway
	Regulation of p38-alpha and p38-beta
	CDC42 signaling events
	Signaling events regulated by Ret tyrosine kinase
	Arf6 signaling events
	Signaling events mediated by TCPTP
	FAS (CD95) signaling pathway
	Thromboxane A2 receptor signaling
	Netrin-mediated signaling events
	Alpha9 beta1 integrin signaling events
	CXCR4-mediated signaling events
	EGF receptor (ErbB1) signaling pathway
	Class I PI3K signaling events
	Posttranslational regulation of adherens junction stability and dissassembly
	Regulation of Androgen receptor activity
	E-cadherin signaling in the nascent adherens junction
	amb2 Integrin signaling
	Integrins in angiogenesis
	ErbB1 downstream signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	ErbB2/ErbB3 signaling events
	EPHA forward signaling
	E-cadherin signaling in keratinocytes
	PDGFR-beta signaling pathway
	Nongenotropic Androgen signaling
	Internalization of ErbB1
	CXCR3-mediated signaling events
	Signaling events mediated by VEGFR1 and VEGFR2
	Syndecan-2-mediated signaling events
	Class I PI3K signaling events mediated by Akt
	Syndecan-3-mediated signaling events
	Ephrin B reverse signaling
	Trk receptor signaling mediated by PI3K and PLC-gamma
	EPHA2 forward signaling
	Alpha-synuclein signaling
	FGF signaling pathway
	Alpha4 beta1 integrin signaling events
	Signaling events mediated by focal adhesion kinase
WikiPathways	ErbB Signaling Pathway
	Senescence and Autophagy in Cancer
	Notch Signaling Pathway
	EPO Receptor Signaling
	EGF/EGFR Signaling Pathway
	TGF beta Signaling Pathway
	Signaling of Hepatocyte Growth Factor Receptor
	Kit receptor signaling pathway
	Pregnane X Receptor pathway
	Aryl Hydrocarbon Receptor Pathway
	IL-3 Signaling Pathway
	Nanoparticle-mediated activation of receptor signaling
	Polycystic Kidney Disease Pathway
	Alpha 6 Beta 4 signaling pathway
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	Signaling Pathways in Glioblastoma
	TSLP Signaling Pathway
	Arylhydrocarbon receptor (AhR) signaling pathway
	Regulation of Microtubule Cytoskeleton
	FSH signaling pathway
	Leptin signaling pathway
	RANKL/RANK Signaling Pathway
	Integrin-mediated Cell Adhesion
	Angiogenesis
	Androgen receptor signaling pathway
References
Ref 546858	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010691)
Ref 535031	Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9373-8.

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Drug Information