Drug Information

Drug General Information
Drug ID
D0BJ2W
Former ID
DIB005170
Drug Name
DAS-431 IV
Indication Dementia [ICD9: 290-294; ICD10:F01-F07] Phase 2 [551849]
Company
DrugAbuse Sciences
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Agonist [526175]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
References
Ref 551849The SAGE Handbook of Healthcare, Decision Resources Inc. Page(548).
Ref 526175Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7(3):305-16.

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