Drug Information

Drug General Information
Drug ID
D0E5KK
Former ID
DIB004191
Drug Name
MGluR2 PAMs
Synonyms
MGluR2 PAMs (CNS disorders); MGluR2 PAMs (CNS disorders), Pfizer
Indication Central nervous system disease [ICD10:G00-G99] Investigative [543747]
Company
Pfizer Inc
Canonical SMILES
FC(F)(Oc1cc(c([C@H]2[C@H](CN(Cc3nc4ncccc4n3C)CC2)C)cc1)<br />F)F
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator [543747]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 543747(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).
Ref 543747(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).

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