Drug Information

Drug General Information
Drug ID
D0LS4U
Former ID
DIB007775
Drug Name
Etrabamine
Synonyms
14839-JL
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Terminated [545467]
Company
Chiesi SA
Formula
C8H12N2S
Canonical SMILES
c12c(ncs1)CCC(C2)NC
CAS Number
CAS 70590-58-8
PubChem Compound ID
68895
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [550139]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 545467Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003368)
Ref 550139WO patent application no. 2009,0568,11, Medicaments.

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