Drug Information

Drug General Information
Drug ID
D0MU0S
Former ID
DNC000602
Drug Name
EM-800
Drug Type
Small molecular drug
Indication Estrogen deficiency [ICD10:E28.39] Discontinued in Phase 3 [546717]
Formula
C39H47NO6
Canonical SMILES
CC1=C(C(OC2=C1C=CC(=C2)OC(=O)C(C)(C)C)C3=CC=C(C=C3)OCCN<br />4CCCCC4)C5=CC=C(C=C5)OC(=O)C(C)(C)C
InChI
1S/C39H47NO6/c1-26-32-20-19-31(45-37(42)39(5,6)7)25-33(32)46-35(34(26)27-11-17-30(18-12-27)44-36(41)38(2,3)4)28-13-15-29(16-14-28)43-24-23-40-21-9-8-10-22-40/h11-20,25,35H,8-10,21-24H2,1-7H3/t35-/m0/s1
InChIKey
OEKMGABCSLYWOP-DHUJRADRSA-N
CAS Number
CAS 182167-03-9
PubChem Compound ID
9873952
PubChem Substance ID
14838931, 14887663, 24163736, 45296209, 77523681, 93165513, 103260302, 103954838, 128797033, 135264126, 142213937, 227995016, 241178694
Target and Pathway
Target(s) Estrogen receptor beta Target Info Antagonist [538072]
Estrogen receptor Target Info Antagonist [538072]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathwayhsa04915:Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear Receptor transcription pathwayR-HSA-1251985:Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear ReceptorsWP712:Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 546717Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009862)
Ref 538072EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Endocrinology. 1998 Jan;139(1):111-8.

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