Drug Information

Drug General Information
Drug ID
D0N3SP
Former ID
DAP001267
Drug Name
Butoconazole
Synonyms
Butaconazole; Butoconazol; Butoconazolum; Femstat; Gynofort; Duplicate RN for parent cpd; RS 35887; Butoconazol [INN-Spanish]; Butoconazole (INN); Butoconazole [INN:BAN]; Butoconazolum [INN-Latin]; Gynofort (TN); RS 35887-10-3; (+-)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole; (+/-)-1-[4-(p-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]imidazole; (-)-1-((4-(p-Chlorophenyl)-2-((2,6-dichlorophenyl)thio)imidazole; 1-(4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl)-1H-imidazole; 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole; 1-{4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl}-1H-imidazole; 1H-Imidazole; 1H-Imidazole, 1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-, nitrate
Drug Type
Small molecular drug
Indication Candidiasis infection [ICD9: 001-139, 112; ICD10:B37] Approved [538547], [551871]
Therapeutic Class
Antifungal Agents
Company
Roche Palo Alto Llc
Formula
C19H17Cl3N2S
Canonical SMILES
C1=CC(=C(C(=C1)Cl)SC(CCC2=CC=C(C=C2)Cl)CN3C=CN=C3)Cl
InChI
1S/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2
InChIKey
SWLMUYACZKCSHZ-UHFFFAOYSA-N
CAS Number
CAS 64872-77-1
PubChem Compound ID
47472
PubChem Substance ID
10265, 606881, 5909436, 7978833, 8180230, 11466436, 11467556, 11486011, 14831130, 34712456, 46508016, 47349476, 47499673, 47573487, 47720717, 49699080, 50065017, 50065047, 50124316, 50245502, 51091909, 57313105, 85175754, 85787532, 92714621, 92729939, 103401138, 104353016, 117463285, 121362178, 124766277, 125355453, 126623993, 126685459, 129298670, 134338503, 135033523, 135079905, 137251869, 138026866, 141777962, 144075681, 152039486, 160963984, 162178690, 164814546, 164827353, 174007468, 175611029, 176484539
SuperDrug ATC ID
G01AF15
SuperDrug CAS ID
cas=064872760
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [537667]
References
Ref 538547FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020421.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537667Effects of terconazole and other azole antifungal agents on the sterol and carbohydrate composition of Candida albicans. Diagn Microbiol Infect Dis. 1990 Jan-Feb;13(1):31-5.

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