Drug Information

Drug General Information
Drug ID
D0O9ZY
Former ID
DIB020838
Drug Name
RO5166017
Synonyms
RO 5166017; RO-5166017
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541171]
Formula
C12H17N3O
InChI
InChI=1S/C12H17N3O/c1-2-15(11-6-4-3-5-7-11)8-10-9-16-12(13)14-10/h3-7,10H,2,8-9H2,1H3,(H2,13,14)/t10-/m0/s1
InChIKey
PPONHQQJLWPUPH-JTQLQIEISA-N
PubChem Compound ID
25016538
PubChem Substance ID
56360131, 57535394, 137228815, 137530438, 138176748, 178102486, 224266310, 226817606, 248447216
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Agonist [531452]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 541171(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5862).
Ref 531452TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.