TTD | Drug: D0P3RF

Drug General Information
Drug ID	D0P3RF
Former ID	DIB019426
Drug Name	compound 3
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529880]
Formula	C14H11BrN4O3S
InChI	InChI=1S/C26H26N6O2/c1-31-10-12-32(13-11-31)21-5-3-4-19-25(21)28-26(27-19)24-18-8-6-16(14-20(18)29-30-24)17-7-9-22(33)23(15-17)34-2/h3-9,14-15,33H,10-13H2,1-2H3,(H,27,28)(H,29,30)
InChIKey	KKMLIJHOUUKCSW-UHFFFAOYSA-N
PubChem Compound ID	5858639
Target and Pathway
Target(s)	mRNA of PKC-zeta	Target Info	Inhibitor	[529880]
Target(s)	Cell division protein kinase 2	Target Info	Inhibitor	[529880]
KEGG Pathway	Rap1 signaling pathway
	Chemokine signaling pathway
	Sphingolipid signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Hippo signaling pathway
	Tight junction
	Platelet activation
	Insulin signaling pathway
	Type II diabetes mellitushsa04068:FoxO signaling pathway
	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Prostate cancer
	Small cell lung cancer
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	VEGF signaling pathway
	Wnt signaling pathway
	5HT2 type receptor mediated signaling pathway
	Histamine H1 receptor mediated signaling pathway
	Oxytocin receptor mediated signaling pathway
	Thyrotropin-releasing hormone receptor signaling pathwayP00059:p53 pathway
	p53 pathway feedback loops 2
Pathway Interaction Database	RhoA signaling pathway
	Insulin Pathway
	Noncanonical Wnt signaling pathway
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	CDC42 signaling events
	Thromboxane A2 receptor signaling
	IL1-mediated signaling events
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	CXCR4-mediated signaling events
	IGF1 pathway
	TNF receptor signaling pathway
	IL2 signaling events mediated by PI3K
	Ceramide signaling pathway
	p75(NTR)-mediated signaling
	amb2 Integrin signaling
	ErbB1 downstream signaling
	Neurotrophic factor-mediated Trk receptor signaling
	Nephrin/Neph1 signaling in the kidney podocyte
	Insulin-mediated glucose transport
	Regulation of Ras family activationsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	E2F transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	FOXM1 transcription factor network
	BARD1 signaling events
	p53 pathway
	Regulation of retinoblastoma protein
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	GPVI-mediated activation cascade
	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
	VEGFR2 mediated cell proliferationR-HSA-1538133:G0 and Early G1
	Activation of ATR in response to replication stress
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	Processing of DNA double-strand break ends
	G2 Phase
	Orc1 removal from chromatin
	Cyclin E associated events during G1/S transition
	Cyclin A/B1 associated events during G2/M transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Calcium Regulation in the Cardiac Cell
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	MAPK Signaling Pathway
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Signaling by TGF-beta Receptor Complex
	Allograft Rejection
	AGE/RAGE pathway
	TNF alpha Signaling Pathway
	Signaling Pathways in Glioblastoma
	miRs in Muscle Cell Differentiation
	IL-1 signaling pathway
	GPVI-mediated activation cascade
	Type II diabetes mellitusWP707:DNA Damage Response
	ID signaling pathway
	DNA Replication
	G1 to S cell cycle control
	M/G1 Transition
	S Phase
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Prostate Cancer
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Synthesis of DNA
	Regulation of DNA replication
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage Response
References
Ref 529880	2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11.
Ref 529880	2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11.

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Drug Information