Drug Information

Drug General Information
Drug ID
D0PL5F
Former ID
DIB007610
Drug Name
OT-4003
Synonyms
IDDB10966
Indication Asthma [ICD10:J45] Terminated [534337]
Company
LEO Pharma A/S
Canonical SMILES
n1c2c(cc(cc2)Cl)ccc1/C=C/c1cc(NCc2c(O[C@H](C(=O)O)CCCCC<br />)cccc2)ccc1
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [534337]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 534337Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. Bioorg Med Chem. 1997 Feb;5(2):415-27.
Ref 534337Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. Bioorg Med Chem. 1997 Feb;5(2):415-27.

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