Drug Information

Drug General Information
Drug ID
D0Q4LG
Former ID
DIB011485
Drug Name
IT-139
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [549255]
Company
Intezyne
Target and Pathway
Target(s) 78 kDa glucose-regulated protein Target Info Inhibitor [544275]
KEGG Pathway Protein export
Protein processing in endoplasmic reticulum
Antigen processing and presentation
Thyroid hormone synthesis
Prion diseases
NetPath Pathway TSH Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Parkinson disease
PathWhiz Pathway Retinol Metabolism
Reactome Platelet degranulation
Regulation of HSF1-mediated heat shock response
WikiPathways MAPK Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Activation of Chaperone Genes by ATF6-alpha
Parkin-Ubiquitin Proteasomal System pathway
Unfolded Protein Response
Response to elevated platelet cytosolic Ca2+
References
Ref 549255Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034247)
Ref 544275NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer. BMC Pharmacol Toxicol. 2012; 13(Suppl 1): A82.

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