Drug Information

Drug General Information
Drug ID
D0RC0J
Former ID
DNCL003048
Drug Name
ABT-436
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Phase 2 [524149]
Company
Abbott Laboratories
Target and Pathway
Target(s) Vasopressin V1b receptor Target Info Modulator [544158]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 524149ClinicalTrials.gov (NCT01741142) Efficacy and Safety Study of ABT-436 in Major Depressive Disorder. U.S. National Institutes of Health.
Ref 544158The vasopressin Avprlb receptor: Molecular and pharmacological studies. Stress. 2011 January; 14(1): 98-115.

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