TTD | Drug: D0T8NU

Drug General Information
Drug ID	D0T8NU
Former ID	DIB019603
Drug Name	compound 89S
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529892]
Formula	C13H14FN5O
InChI	InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m0/s1
InChIKey	LCBAQTCTQXHTJG-ZETCQYMHSA-N
PubChem Compound ID	16757525
PubChem Substance ID	26746519, 46580560, 57299089, 99443620, 103628176, 160968234, 170482212, 180411556, 245106743, 249565794
Target and Pathway
Target(s)	Glycogen synthase kinase-3 beta	Target Info	Inhibitor	[529892]
	Cell division control protein 2 homolog	Target Info	Inhibitor	[529892]
	TAO kinase 3	Target Info	Inhibitor	[529892]
	CDC7 protein kinase	Target Info	Inhibitor	[529892]
	Cell division protein kinase 2	Target Info	Inhibitor	[529892]
	Cell division protein kinase 9	Target Info	Inhibitor	[529892]
KEGG Pathway	ErbB signaling pathway
	Chemokine signaling pathway
	Cell cycle
	PI3K-Akt signaling pathway
	Wnt signaling pathway
	Hedgehog signaling pathway
	Axon guidance
	Hippo signaling pathway
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Dopaminergic synapse
	Insulin signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Alzheimer's disease
	Hepatitis C
	Measles
	Influenza A
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Colorectal cancer
	Endometrial cancer
	Prostate cancer
	Basal cell carcinomahsa04110:Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Gap junction
	Progesterone-mediated oocyte maturation
	Herpes simplex infection
	Viral carcinogenesishsa04068:FoxO signaling pathway
	Hepatitis B
	Viral carcinogenesis
	Small cell lung cancerhsa05202:Transcriptional misregulation in cancer
NetPath Pathway	RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Angiogenesis
	Cadherin signaling pathway
	Hedgehog signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Interleukin signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	Wnt signaling pathway
	Ras Pathway
	CCKR signaling map STP00059:p53 pathway
	p53 pathway feedback loops 2
Pathway Interaction Database	LPA receptor mediated events
	Degradation of beta catenin
	Reelin signaling pathway
	Presenilin action in Notch and Wnt signaling
	Integrin-linked kinase signaling
	CDC42 signaling events
	LKB1 signaling events
	Canonical Wnt signaling pathway
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	C-MYC pathway
	Regulation of Androgen receptor activity
	BMP receptor signaling
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Validated transcriptional targets of deltaNp63 isoforms
	Aurora A signaling
	Insulin-mediated glucose transport
	Class I PI3K signaling events mediated by Akt
	p53 pathway
	Trk receptor signaling mediated by PI3K and PLC-gammap73pathway:p73 transcription factor network
	E2F transcription factor network
	PLK1 signaling events
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Retinoic acid receptors-mediated signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	BARD1 signaling events
	Regulation of retinoblastoma protein
Reactome	Degradation of beta-catenin by the destruction complex
	AKT phosphorylates targets in the cytosol
	Regulation of HSF1-mediated heat shock response
	CRMPs in Sema3A signaling
	Disassembly of the destruction complex and recruitment of AXIN to the membrane
	S33 mutants of beta-catenin aren't phosphorylated
	S37 mutants of beta-catenin aren't phosphorylated
	S45 mutants of beta-catenin aren't phosphorylated
	T41 mutants of beta-catenin aren't phosphorylated
	Degradation of GLI2 by the proteasome
	Constitutive Signaling by AKT1 E17K in CancerR-HSA-110056:MAPK3 (ERK1) activation
	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cyclin B2 mediated events
	Golgi Cisternae Pericentriolar Stack Reorganization
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	Phosphorylation of the APC/C
	Phosphorylation of Emi1
	Condensation of Prophase Chromosomes
	MASTL Facilitates Mitotic Progression
	Resolution of Sister Chromatid Cohesion
	Condensation of Prometaphase Chromosomes
	Regulation of PLK1 Activity at G2/M Transition
	Activation of NIMA Kinases NEK9, NEK6, NEK7
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Recruitment of NuMA to mitotic centrosomes
	Depolymerisation of the Nuclear Lamina
	Anchoring of the basal body to the plasma membrane
	MAPK6/MAPK4 signaling
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	G2/M DNA replication checkpoint
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-1538133:G0 and Early G1
	Activation of ATR in response to replication stress
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	Processing of DNA double-strand break ends
	G2 Phase
	Orc1 removal from chromatin
	Cyclin E associated events during G1/S transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet productionR-HSA-2173796:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
WikiPathways	DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Notch Signaling Pathway
	Glycogen Metabolism
	Insulin Signaling
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	IL-6 signaling pathway
	Wnt Signaling Pathway Netpath
	Copper homeostasis
	Focal Adhesion
	Hair Follicle Development: Induction (Part 1 of 3)
	Cardiac Hypertrophic Response
	Degradation of beta-catenin by the destruction complex
	T-Cell Receptor and Co-stimulatory Signaling
	Cardiac Progenitor Differentiation
	BDNF signaling pathway
	Corticotropin-releasing hormone
	B Cell Receptor Signaling Pathway
	IL17 signaling pathway
	Neural Crest Differentiation
	Alzheimers Disease
	IL-7 Signaling Pathway
	Regulation of Microtubule Cytoskeleton
	TWEAK Signaling Pathway
	Leptin signaling pathway
	Semaphorin interactions
	Cell Cycle
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
	IL-5 Signaling PathwayWP707:DNA Damage Response
	G1 to S cell cycle control
	TGF beta Signaling Pathway
	PPAR Alpha Pathway
	MAP kinase activation in TLR cascade
	RAF/MAP kinase cascade
	Mitotic Prophase
	Mitotic Prometaphase
	BMI1
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Prostate Cancer
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
	ID signaling pathway
	DNA Replication
	M/G1 Transition
	S Phase
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Synthesis of DNA
	Regulation of DNA replication
	Factors involved in megakaryocyte development and platelet production
	miRNA Regulation of DNA Damage ResponseWP2795:Cardiac Hypertrophic Response
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Host Interactions of HIV factors
HIV Life Cycle
IL-9 Signaling Pathway
RNA Polymerase II Transcription
References
Ref 529892	First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307.
Ref 529892	First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307.

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Drug Information