Drug Information

Drug General Information
Drug ID
D0W1YV
Former ID
DIB008798
Drug Name
PLX-5622
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 1 [523330]
Company
Plexxikon Inc
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Inhibitor [544233]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 523330ClinicalTrials.gov (NCT01282684) Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PLX5622 in Healthy Adult Volunteers. U.S. National Institutes of Health.
Ref 544233Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527.

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